A new study published in the American Journal of Clinical Nutrition suggests that pregnant women who take at least 600 milligrams per day of folic acid- in the first month of pregnancy - have a 38 percent lower chance of having a child with autism or Asperger's.
Folic acid, the synthetic form of the B-vitamin folate, has been added to breakfast cereals and other grains in the United States since 1998 because of evidence showing deficiencies in pregnant women made it more likely their babies would have brain and spine birth defects.
Questions remain about whether a lack of the vitamin, or difficulty processing it, might increase the risk of mental retardation and certain developmental disorders as well.
Folate "becomes very critical in the early stages of life… as well as the first year of life, when basically the brain is establishing connections and functions," said Edward Quadros from SUNY Downstate Medical Center in Brooklyn, New York.
"If there is a folate deficiency, this disrupts a lot of functioning with the brain," Quadros, who has studied autism and folic acid but wasn't involved in the new research, told Reuters Health.
On the other side of the coin is the belief some scientists have that the children of women who take too much folic acid during pregnancy may be at a higher risk for autism.
"There were a lot of hypotheses on how perhaps the folic acid fortification in the U.S. was responsible for the increased prevalence of autism spectrum disorders, so that was also a concern," said Rebecca Schmidt, the lead author of the new study from the University of California, Davis.
"When we starting looking at this, I thought it could go either way," she said.
The study involved moms in California. They were asked about their folic acid intake during pregnancy.
Schmidt and her colleagues surveyed the mothers of 429 preschoolers with an autism spectrum disorder and 278 with normal development about their diet and supplement use before and during pregnancy. Using that information, they calculated how much daily folic acid women were getting each month.
Throughout their pregnancies, mothers of kids without autism got more folic acid through fortified foods and vitamins than those who ended up having an autistic child.
That difference was greatest in the first month of pregnancy, when mothers of normally-developing babies remembered getting an average 779 micrograms of folic acid daily and 69 percent of them at least met the daily guidelines.
That compared to an average 655 micrograms in moms of autistic kids, 54 percent of who got the recommended 600 micrograms or more per day.
One limitation is the women had to remember their month-to-month diets and supplement use from a few years ago by the time they were surveyed, which makes their reports less reliable. Even with the new findings, there's no proof that had some moms in the study gotten more folic acid in their pregnancy diets, their children wouldn't have developed an autism spectrum disorder.
The link between folic acid and autism remained in the new study when Schmidt's team took into account mothers' age and race as well as whether they smoked or drank alcohol during their pregnancy.
Not all researchers are convinced that there is a link between folic acid and autism.
"I would be very careful," said Dr. Fernando Scaglia, who has also studied autism and folate deficiency at Baylor College of Medicine in Houston, Texas.
"I think that more studies need to be done to see if this can be replicated."
For now, when it comes to folic acid during pregnancy, Schmidt said, "The recommendations that are out there already are pretty good to follow."